Why is losing Twine a massive blow. We have no idea what his impact would or would not be. Played one full game. Hardly enough to suggest that it is a massive blow.
Perhaps if Manning played Knight in his natural position with Conway as a 10 we may not have needed Twine in the first place.
I accept long term we need more creativity, but why not try and use the players we already have (mehmeti has played 10, so has Sykes, i think) and coaching them to be better.